Form 8-K

8-K — VYNE Therapeutics Inc.

Accession: 0001104659-26-085235

Filed: 2026-07-21

Period: 2026-07-21

CIK: 0001566044

SIC: 2834 (PHARMACEUTICAL PREPARATIONS)

Item: Regulation FD Disclosure

Item: Other Events

Item: Financial Statements and Exhibits

Documents

8-K — tm2620874d1_8k.htm (Primary)

EX-99.1 — EXHIBIT 99.1 (tm2620874d1_ex99-1.htm)

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8-K — FORM 8-K

8-K (Primary)

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UNITED STATES

SECURITIES AND EXCHANGE COMMISSION

Washington, D.C. 20549

FORM 8-K

CURRENT REPORT

Pursuant to Section 13 or 15(d) of the

Securities Exchange Act of 1934

Date of Report (Date of earliest event reported):

July 21, 2026

VYNE

Therapeutics Inc.

(Exact Name of Registrant as Specified in its

Charter)

Delaware

001-38356

45-3757789

(State

or Other Jurisdiction

of Incorporation)

(Commission

File

Number)

(IRS

Employer

Identification No.)

P.O. Box 125, Stewartsville, NJ

08886

(Address of Principal Executive Offices)

(Zip Code)

Registrant’s telephone number, including area code: (800) 775-7936

Check the appropriate box below if the Form 8-K filing

is intended to simultaneously satisfy the filing obligation of the registrant under any of the following provisions:

Written communications pursuant to Rule 425 under the Securities Act (17 CFR 230.425)

Soliciting material pursuant to Rule 14a-12 under the Exchange Act (17

CFR 240.14a-12)

Pre-commencement communications pursuant to Rule 14d-2(b) under

the Exchange Act (17 CFR 240.14d-2(b))

Pre-commencement communications pursuant to Rule 13e-4(c) under

the Exchange Act (17 CFR 240.13e-4(c))

Securities registered pursuant to Section 12(b) of the Securities Exchange Act of 1934:

Title

of each class

Trading

symbol

Name

of each exchange

on which registered

Common

Stock, $0.0001 par value

VYNE

The Nasdaq Stock Market LLC

Indicate by check mark whether the registrant is an emerging growth

company as defined in Rule 405 of the Securities Act of 1933 (§230.405 of this chapter) or Rule 12b-2 of the Securities

Exchange Act of 1934 (§240.12b-2 of this chapter).

Emerging growth company ¨

If an emerging growth company, indicate by check mark if the registrant

has elected not to use the extended transition period for complying with any new or revised financial accounting standards provided pursuant

to Section 13(a) of the Exchange Act. ¨

As previously disclosed, on December 17,

2025, VYNE Therapeutics Inc., a Delaware corporation (“VYNE” or the “Company”), entered into an Agreement and

Plan of Merger and Reorganization (as amended, the “Merger Agreement”), by and among VYNE, Yellow Merger Sub Corp., a Delaware

corporation and a wholly owned subsidiary of VYNE (“Merger Sub”), and Yarrow Bioscience, Inc., a Delaware corporation

(“Yarrow”), pursuant to which, and subject to the satisfaction or waiver of the conditions set forth in the Merger Agreement,

among other things, Merger Sub will merge with and into Yarrow, with Yarrow continuing as a wholly owned subsidiary of VYNE and the surviving

corporation of the merger (the “Merger”).

Item 7.01 Regulation FD Disclosure.

On July 21, 2026, VYNE issued a press release titled “VYNE

Therapeutics Announces 1-for-50 Reverse Stock Split and Provides Update Regarding Special Dividend in Connection with the Proposed Merger

with Yarrow Bioscience.” A copy of the press release is being furnished as Exhibit 99.1 to this Current Report on Form 8-K.

The information under Item 7.01 of this Current

Report on Form 8-K (including Exhibit 99.1) is intended to be furnished and shall not be deemed “filed” for purposes

of Section 18 of the Securities Exchange Act of 1934, as amended (the “Exchange Act”), or otherwise subject to the liabilities

of that section, nor shall it be deemed incorporated by reference in any filing under the Securities Act of 1933, as amended (the “Securities

Act”), or the Exchange Act, except as expressly set forth by specific reference in such filing.

Item 8.01 Other Events.

At the special meeting in lieu of the annual meeting of VYNE stockholders

on July 16, 2026 (the “Special Meeting”), VYNE’s stockholders approved a proposal to amend the amended and restated

certificate of incorporation of VYNE (the “VYNE Charter”) to effect a reverse stock split of issued and outstanding common

stock of VYNE, par value $0.0001 per share (the “VYNE Common Stock”), at a ratio determined by the VYNE board of directors

and agreed to by Yarrow, of one new share of VYNE Common Stock for every 10 to 70 shares (or any number in between) of outstanding VYNE

Common Stock, in the form attached as Annex C to the Company’s definitive proxy statement/prospectus filed on Form S-4 with

the Securities and Exchange Commission (the “SEC”), most recently amended on June 3, 2026 and declared effective on June 15,

2026 (as amended, the “Proxy Statement”) and first mailed to the Company’s stockholders on June 15, 2026. Following

this approval, the VYNE board of directors approved the reverse stock split (the “Reverse Stock Split”) of issued and outstanding

VYNE Common Stock at a final ratio, agreed to by Yarrow, of 1-for-50 shares of VYNE Common Stock (the “Split Ratio”).

Prior to the closing of the Merger, VYNE will

file a certificate of amendment to the VYNE Charter with the Secretary of State of the State of Delaware to effect the Reverse Stock Split.

Upon the effectiveness of such amendment (the “Reverse Stock Split Effective Time”), every 50 shares of VYNE Common Stock

outstanding immediately prior to the Reverse Stock Split Effective Time will be combined and reclassified, automatically and without any

action on the part of VYNE or its stockholders, into one share of VYNE Common Stock, in accordance with the Split Ratio. The Reverse Stock

Split will be realized simultaneously for all shares of VYNE Common Stock and options to purchase shares of VYNE Common Stock outstanding

immediately prior to the Reverse Stock Split Effective Time. The Reverse Stock Split will affect all holders of shares of VYNE Common

Stock uniformly and each such stockholder will hold the same percentage of VYNE Common Stock outstanding immediately following the Reverse

Stock Split as that stockholder held immediately prior to the Reverse Stock Split, except for immaterial adjustments that may result from

the treatment of fractional shares. No fractional shares of VYNE Common Stock will be issued as a result of the Reverse Stock Split. Stockholders

of record who otherwise would be entitled to receive fractional shares because they hold a number of pre-split shares not evenly divisible

by the number of pre-split shares for which each post-split share is to be reclassified, will be entitled to a cash payment (without interest)

in lieu thereof at a price equal to the fraction of a share to which the stockholder would otherwise be entitled multiplied by the closing

trading price of VYNE Common Stock on Nasdaq on the last trading day immediately prior to the date of the Reverse Stock Split Effective

Time.

As of the record date for the Special Meeting,

150,000,000 shares of VYNE Common Stock were authorized and 33,385,055 shares of VYNE Common Stock were outstanding. The Reverse Stock

Split is expected to reduce the number of VYNE’s outstanding shares of VYNE Common Stock from approximately 33.4 million shares

to approximately 0.7 million shares. The Reverse Stock Split will not change the par value of VYNE Common Stock or preferred stock

and will not reduce the number of authorized shares of VYNE Common Stock or preferred stock. At the Special Meeting, VYNE’s stockholders

separately approved Proposal No. 3 to increase the number of shares of VYNE Common Stock that VYNE is authorized to issue from 150,000,000

to 300,000,000 shares in connection with the closing of the Merger.

In addition, effective as of the Reverse Stock

Split Effective Time and as a result of the Reverse Stock Split, proportionate adjustments will be made to the per share exercise price

and the number of shares issuable upon the exercise, vesting or settlement of all outstanding options to purchase shares of VYNE Common

Stock, and the number of shares reserved for issuance pursuant to VYNE’s existing equity incentive and employee stock purchase plans

will be reduced proportionately based on the Split Ratio. VYNE Common Stock issued pursuant to the Reverse Stock Split will remain fully

paid and nonassessable. The Reverse Stock Split will not affect VYNE continuing to be subject to the periodic reporting requirements of

the Exchange Act.

Following the Reverse Stock Split Effective Time

and consummation of the Merger, the combined company’s common stock is expected to commence trading on a split-adjusted, post-Merger

basis on Nasdaq under the name “Yarrow Bioscience, Inc.” and ticker symbol “YARW” at the open of trading

on July 27, 2026, at which time the common stock will be represented by a new CUSIP Number (92941V407) and ISIN Number (US92941V4077).

Following the Reverse Stock Split and the

closing of the Merger, the combined company’s total issued and outstanding common stock is expected to be approximately 2.7

million shares, or approximately 33.6 million shares on a fully-diluted basis, or approximately 28.6 million shares excluding shares

underlying equity plans and awards.

Item 9.01 Financial Statements and Exhibits.

(d) Exhibits

Exhibit

No.

Description

99.1

Press

Release issued by VYNE Therapeutics Inc. on July 21, 2026, furnished herewith.

104

Cover Page Interactive Data File (embedded within the Inline XBRL document)

Forward-Looking Statements

This Current Report on Form 8-K contains

forward-looking statements (including within the meaning of the Exchange Act, and Section 27A of the Securities Act) concerning VYNE,

Yarrow, the proposed transactions and other matters. These forward-looking statements include express or implied statements relating to

the structure, timing and completion of the proposed Merger; the expected Reverse Stock Split, including the timing thereof; and other

statements that are not historical fact. The words “anticipate,” “believe,” “contemplate,” “continue,”

“could,” “estimate,” “expect,” “intend,” “may,” “might,” “plan,”

“possible,” “potential,” “predict,” “project,” “should,” “will,”

“would” and similar expressions (including the negatives of these terms or variations of them) may identify forward-looking

statements, but the absence of these words does not mean that a statement is not forward-looking. These forward-looking statements are

based on current expectations and beliefs concerning future developments and their potential effects. There can be no assurance that future

developments affecting VYNE, Yarrow or the proposed transactions will be those that have been anticipated.

The forward-looking statements contained in this

Current Report on Form 8-K are based on current expectations and beliefs concerning future developments and their potential effects

and therefore are subject to other risks and uncertainties. These risks and uncertainties include, but are not limited to, risks associated

with the possible failure to satisfy the conditions to the closing or consummation of the Merger; risks associated with the uncertainty

as to the timing of the consummation of the Merger and the ability of each of VYNE and Yarrow to consummate the transactions contemplated

by the Merger; the occurrence of any event, change or other circumstance or condition that could give rise to the termination of the Merger

prior to the closing or consummation of the Merger; risks associated with the possible failure to realize certain anticipated benefits

of the Merger, including with respect to future financial and operating results; the effect of the completion of the Merger on the combined

company’s business relationships, operating results and business generally; risks associated with the combined company’s ability

to manage expenses and unanticipated spending and costs that could reduce the combined company’s cash resources; risks related to

the combined company’s ability to correctly estimate its operating expenses and other events; changes in capital resource requirements;

risks related to the inability of the combined company to obtain sufficient additional capital to continue to advance its product candidates

or its preclinical programs; the outcome of any legal proceedings that may be instituted against the combined company or any of its directors

or officers related to the Merger Agreement or the transactions contemplated thereby; the ability of the combined company to obtain, maintain

and protect its intellectual property rights, in particular those related to its product candidates; the combined company’s ability

to advance the development of its product candidates or preclinical activities under the timelines it anticipates in planned and future

clinical trials; the combined company’s ability to replicate in later clinical trials positive results found in preclinical studies

and early-stage clinical trials of its product candidates; the combined company’s ability to realize the anticipated benefits of

its research and development programs, strategic partnerships, licensing programs or other collaborations; regulatory requirements or

developments and the combined company’s ability to obtain necessary approvals from the U.S. Food and Drug Administration or other

regulatory authorities; changes to clinical trial designs and regulatory pathways; competitive responses to the Merger and changes in

expected or existing competition; unexpected costs, charges or expenses resulting from the Merger; potential adverse reactions or changes

to business relationships resulting from the completion of the Merger; legislative, regulatory, political and economic developments; changes

in the net cash of VYNE and the per share dividend amount, each as determined in accordance with the terms of the Merger Agreement, relative

to the currently estimated amounts; and those risks and uncertainties and other factors more fully described in filings with the SEC,

including reports filed on Form 10-K, 10-Q and 8-K and in other filings made by VYNE with the SEC from time to time and available

at www.sec.gov. These forward-looking statements are based on current expectations, and with regard to the proposed transactions, are

based on VYNE’s current expectations, estimates and projections about the expected date of closing of the proposed Merger and the

potential benefits thereof, its business and industry, management’s beliefs and certain assumptions made by VYNE, all of which are

subject to change. Such forward-looking statements are made as of the date of this Current Report on Form 8-K, and the parties undertake

no obligation to update such statements to reflect subsequent events or circumstances, except as otherwise required by securities and

other applicable law.

No Offer or Solicitation

This Current Report on Form 8-K is not intended

to and does not constitute (i) a solicitation of a proxy, consent or approval with respect to any securities or in respect of the

proposed transactions or (ii) an offer to sell or the solicitation of an offer to subscribe for or buy or an invitation to purchase

or subscribe for any securities pursuant to the proposed transactions or otherwise, nor shall there be any sale, issuance or transfer

of securities in any jurisdiction in contravention of applicable law. No offer of securities shall be made except by means of a prospectus

meeting the requirements of the Securities Act or an exemption therefrom. Subject to certain exceptions to be approved by the relevant

regulators or certain facts to be ascertained, the public offer will not be made directly or indirectly, in or into any jurisdiction where

to do so would constitute a violation of the laws of such jurisdiction, or by use of the mails or by any means or instrumentality (including

without limitation, facsimile transmission, telephone and the internet) of interstate or foreign commerce, or any facility of a national

securities exchange, of any such jurisdiction.

NEITHER THE SEC NOR ANY STATE SECURITIES COMMISSION

HAS APPROVED OR DISAPPROVED OF THE SECURITIES OR DETERMINED IF THIS CURRENT REPORT ON FORM 8-K IS TRUTHFUL OR COMPLETE.

SIGNATURES

Pursuant to the requirements of the Securities

Exchange Act of 1934, the registrant has duly caused this report to be signed on its behalf by the undersigned hereunto duly authorized.

VYNE THERAPEUTICS INC.

Date: July 21, 2026

/s/ Mutya Harsch

Mutya Harsch

Chief Legal Officer and General Counsel

EX-99.1 — EXHIBIT 99.1

EX-99.1

Filename: tm2620874d1_ex99-1.htm · Sequence: 2

Exhibit 99.1

VYNE Therapeutics Announces 1-for-50 Reverse

Stock Split and Provides Update Regarding Special Dividend in Connection with the Proposed Merger with Yarrow Bioscience

Aggregate cash dividend of $17.3 million, or approximately $0.40242

per share

NEW YORK, N.Y., July 21, 2026-- VYNE Therapeutics Inc. (Nasdaq: VYNE)

(“VYNE” or the “Company”) today announced that its Board of Directors has approved a reverse stock split of VYNE’s

common stock at a ratio of 1-for-50 in connection with the anticipated closing of the proposed merger (the “Merger”) with

Yarrow Bioscience, Inc. (“Yarrow”). The reverse stock split was previously approved by VYNE’s stockholders at VYNE’s

special meeting in lieu of the annual meeting of stockholders held on July 16, 2026 (the “Special Meeting”). Following the

Merger, the combined company’s common stock is expected to begin trading on a post-reverse stock split basis on The Nasdaq Capital

Market (“Nasdaq”) on July 27, 2026, under the new name “Yarrow Bioscience, Inc.”, ticker symbol “YARW”,

CUSIP Number 92941V407 and ISIN Number US92941V4077.

The reverse stock split is expected to reduce the number of shares

of VYNE’s outstanding common stock from approximately 33.4 million shares to approximately 0.7 million shares. The number of shares

of VYNE’s authorized common stock will not be affected by the reverse stock split. At the Special Meeting, VYNE’s stockholders

approved an increase in the number of shares of VYNE’s authorized common stock from 150,000,000 shares to 300,000,000 shares in

connection with the anticipated closing of the Merger. No fractional shares will be issued if, as a result of the reverse stock split,

a stockholder would otherwise become entitled to a fractional share because the number of shares of VYNE common stock they hold before

the reverse stock split is not evenly divisible by the split ratio. Instead, each stockholder will be entitled to receive a cash payment

(without interest) in lieu of such fractional share. The cash payment to be paid will be equal to the fraction of a share to which such

stockholder would otherwise be entitled multiplied by the closing price per share as reported by The Nasdaq Stock Market LLC on July 23,

2026, as adjusted to give effect to the reverse stock split. As a result of the reverse stock split, proportionate adjustments will be

made to the exercise prices and number of shares of VYNE’s common stock underlying VYNE’s outstanding equity awards. There

will be no change to the par value per share.

In addition, VYNE is providing an update to the previously announced

special cash dividend (the “Cash Dividend”) that was declared in connection with the terms and conditions of the Agreement

and Plan of Merger and Reorganization, entered into on December 17, 2025, as amended, with Yarrow and Yellow Merger Sub Corp. (the “Merger

Agreement”). Today, VYNE is announcing that an aggregate Cash Dividend of $17.3 million, or approximately $0.40242 per share based

on 42,989,506 shares of VYNE common stock and common stock equivalents outstanding as of July 20, 2026, will be payable in cash to VYNE’s

stockholders of record as of July 22, 2026 (the “Record Date”), subject to the Nasdaq due bill procedures described below,

based on their holdings as of the Record Date and during the Due Bill Period (as defined below) and prior to the reverse stock split.

The Cash Dividend will also be payable to VYNE’s warrant holders of record as of the Record Date.

Because the Cash Dividend per share exceeds 25% of VYNE’s stock

price on the declaration date, it is subject to an ex-dividend date of one business day after the Cash Dividend is distributed to the

Company’s stockholders and warrant holders as of the Record Date, which distribution is expected to occur on July 23, 2026 (the

“Payment Date”). Accordingly, Nasdaq is expected to set July 24, 2026 as the ex-dividend date for the Cash Dividend.

In addition, VYNE understands that trades of VYNE’s common stock

entered into during the due bill period, which is expected to begin July 21, 2026 (the business day before the Record Date) and continue

through the Payment Date (the “Due Bill Period”), will have a due bill attached for the Cash Dividend. Due bills obligate

sellers of VYNE common stock to deliver the Cash Dividend to the buyer of such common stock during the Due Bill Period. This means that

persons who purchase VYNE common stock during the Due Bill Period (even if the trade will settle after the Due Bill Period) are entitled

to receive the Cash Dividend, and persons who sell the stock during the Due Bill Period (even if the trade will settle after the Due Bill

Period) are not entitled to the Cash Dividend. Accordingly, if an investor wishes to receive the Cash Dividend, the investor will need

to hold the securities through and including the Payment Date.

The due bill obligations are settled customarily between the brokers

representing the buyers and sellers of the stock. Buyers and sellers of VYNE common stock should consult with their broker before trading

to ensure they understand the effect of Nasdaq’s due bill procedures. VYNE has no obligations for either the amount of the due bill

or the processing of the due bill.

As previously announced, the closing of the Merger is expected to occur

on or about July 24, 2026, assuming the satisfaction or waiver of all conditions under the Merger Agreement.

Following the reverse stock split and the closing of the Merger, the

combined company’s total issued and outstanding common stock is expected to be approximately 2.7 million shares, or approximately

33.6 million shares on a fully-diluted basis, or approximately 28.6 million shares excluding shares underlying equity plans and awards.

About VYNE Therapeutics Inc.

VYNE is a clinical-stage biopharmaceutical company focused on developing

differentiated therapies to treat inflammatory and immune-mediated conditions with high unmet need. VYNE’s unique and proprietary

BET inhibitors, which comprise its InhiBET™ platform, are designed to overcome limitations of early generation BET inhibitors by

leveraging alternative routes of administration and enhanced selectivity. For more information, please visit www.vynetherapeutics.com.

About Yarrow Bioscience, Inc.

Yarrow is a clinical-stage biotechnology company focused on developing

transformative therapies for autoimmune thyroid diseases. Yarrow is developing YB-101, a potentially first-in-class anti-thyroid stimulating

hormone receptor (TSHR) monoclonal antibody designed to directly and rapidly disrupt the central mechanism of both Graves’ disease

and thyroid eye disease. For more information, please visit www.yarrowbioscience.com.

Forward-Looking Statements

This communication contains forward-looking statements (including within

the meaning of Section 21E of the Exchange Act and Section 27A of the Securities Act) concerning the Company, Yarrow, the proposed transactions

and other matters. These forward-looking statements include express or implied statements relating to the structure, timing and completion

of the proposed Merger; the expected reverse stock split, including the timing thereof; and other statements that are not historical fact.

The words “anticipate,” “believe,” “contemplate,” “continue,” “could,” “estimate,”

“expect,” “intend,” “may,” “might,” “plan,” “possible,” “potential,”

“predict,” “project,” “should,” “will,” “would” and similar expressions (including

the negatives of these terms or variations of them) may identify forward-looking statements, but the absence of these words does not mean

that a statement is not forward-looking. These forward-looking statements are based on current expectations and beliefs concerning future

developments and their potential effects. There can be no assurance that future developments affecting the Company, Yarrow or the proposed

transaction will be those that have been anticipated.

The forward-looking statements contained in this communication are

based on current expectations and beliefs concerning future developments and their potential effects and therefore are subject to other

risks and uncertainties. These risks and uncertainties include, but are not limited to, risks associated with the possible failure to

satisfy the conditions to the closing or consummation of the Merger; risks associated with the uncertainty as to the timing of the consummation

of the Merger and the ability of each of the Company and Yarrow to consummate the transactions contemplated by the Merger; the occurrence

of any event, change or other circumstance or condition that could give rise to the termination of the Merger prior to the closing or

consummation of the Merger; risks associated with the possible failure to realize certain anticipated benefits of the Merger, including

with respect to future financial and operating results; the effect of the completion of the Merger on the combined company’s business

relationships, operating results and business generally; risks associated with the combined company’s ability to manage expenses

and unanticipated spending and costs that could reduce the combined company’s cash resources; risks related to the combined company’s

ability to correctly estimate its operating expenses and other events; changes in capital resource requirements; risks related to the

inability of the combined company to obtain sufficient additional capital to continue to advance its product candidates or its preclinical

programs; the outcome of any legal proceedings that may be instituted against the combined company or any of its directors or officers

related to the Merger Agreement or the transactions contemplated thereby; the ability of the combined company to obtain, maintain and

protect its intellectual property rights, in particular those related to its product candidates; the combined company’s ability