MediWound Reports Fourth Quarter and Full Year 2025 Financial Results
EscharEx ® Phase III VALUE trial advancing as planned
Expanded NexoBrid ® manufacturing facility operational; regulatory approvals expected in 2026
$17 million revenue in 2025; $54 million in cash at year-end; 2026–2028 revenue guidance reaffirmed
Conference Call Today, March 5, 2026, at 8:30 a.m. Eastern Time
YAVNE, Israel, March 05, 2026 (GLOBE NEWSWIRE) -- MediWound Ltd. (Nasdaq: MDWD), a global leader in next-generation enzymatic therapeutics for tissue repair, today announced financial results for the fourth quarter and full year ended December 31, 2025.
“We entered 2026 with two strategic growth drivers,” said Ofer Gonen, Chief Executive Officer of MediWound. “Our Phase III VALUE trial of EscharEx continues to progress as planned, with key clinical milestones, including interim assessment and enrollment completion, anticipated by year-end. In parallel, our expanded NexoBrid manufacturing facility is now operational, positioning us to support global demand following regulatory approvals. With these value-creating catalysts, a strong balance sheet, and an experienced team, MediWound is now well-positioned to advance into a new phase of scale and commercial readiness.”
Fourth Quarter 2025 Highlights, Recent Developments, and Upcoming Milestones
EscharEx ®
NexoBrid ®
Fourth Quarter 2025 Financial Highlights
Full Year 2025 Financial Highlights
2026–2028 Outlook
Balance Sheet Highlights
Conference Call and Webcast
MediWound management will host a conference call for investors on Thursday, March 5, 2026, beginning at 8:30 a.m., Eastern Time to discuss these results and answer questions. Shareholders and other interested parties may join the conference call by dialing 1-844-676-8833 (in the U.S.), 1-80-921-2373 (Israel), or 1-412-634-6869 (outside the U.S. & Israel). The call will be available via webcast by clicking HERE or on the Events & Presentations page of the Company’s website.
A replay of the call will be available on the Company’s website at www.mediwound.com.
Non-IFRS Financial Measures
To supplement consolidated financial statements prepared and presented in accordance with IFRS, the Company has provided a supplementary non-IFRS measure to consider in evaluating the Company’s performance. Management uses Adjusted EBITDA, which it defines as earnings before interest, taxes, depreciation and amortization, impairment, one-time expenses, restructuring and share-based compensation expenses.
Although Adjusted EBITDA is not a measure of performance or liquidity calculated in accordance with IFRS, we believe the non-IFRS financial measures we present provide meaningful supplemental information regarding our operating results primarily because they exclude certain non-cash charges or items that we do not believe are reflective of our ongoing operating results when budgeting, planning and forecasting and determining compensation, and when assessing the performance of our business with our senior management. However, investors should not consider these measures in isolation or as substitutes for operating income, cash flows from operating activities or any other measure for determining the Company’s operating performance or liquidity that is calculated in accordance with IFRS. In addition, because Adjusted EBITDA is not calculated in accordance with IFRS, it may not necessarily be comparable to similarly titled measures employed by other companies. The non-IFRS measures included in this press release have been reconciled to the IFRS results in the tables below.
About MediWound
MediWound Ltd. (Nasdaq: MDWD) is a global biotechnology company pioneering enzymatic, non-surgical therapies for tissue repair. The company’s FDA-approved biologic, NexoBrid ®, is indicated for the enzymatic removal of eschar in thermal burns and is marketed in the United States, European Union, Japan, and additional international markets. MediWound’s late-stage pipeline product, EscharEx ®, is an investigational therapy for the debridement of chronic wounds, with potential to become a new standard of care in wound management.
For more information, visit www.mediwound.com and follow us on LinkedIn and X (formerly Twitter).
Cautionary Note Regarding Forward-Looking Statements
MediWound cautions you that all statements other than statements of historical fact included in this press release that address activities, events, or developments that we expect, believe, or anticipate will or may occur in the future are forward-looking statements. Although we believe that we have a reasonable basis for the forward-looking statements contained herein, they are based on current expectations about future events affecting us and are subject to risks, assumptions, uncertainties, and factors, all of which are difficult to predict and many of which are beyond our control. Actual results may differ materially from those expressed or implied by the forward-looking statements in this press release. These statements are often, but are not always, made through the use of words or phrases such as “anticipates,” “intends,” “estimates,” “plans,” “expects,” “continues,” “believe,” “guidance,” “outlook,” “target,” “future,” “potential,” “goals” and similar words or phrases, or future or conditional verbs such as “will,” “would,” “should,” “could,” “may,” or similar expressions.
Specifically, this press release contains forward-looking statements concerning the anticipated progress, development, study design, expected data timing, objectives anticipated timelines, expectations and commercial potential of our products and product candidates, including EscharEx ® and NexoBrid ®. Among the factors that may cause results to be materially different from those stated herein are the inherent uncertainties associated with the uncertain, lengthy and expensive nature of the product development process; the timing and conduct of our studies of our products and product candidates, including the timing, progress and results of current and future clinical studies, and our research and development programs; the approval of regulatory submission by the FDA, the European Medicines Agency or by any other regulatory authority, our ability to obtain marketing approval of our products and product candidates in the U.S. or other markets; our contracts with governmental agencies; the clinical utility, potential advantages and timing or likelihood of regulatory filings and approvals of our products and products; our expectations regarding future growth, including our ability to develop new products; market acceptance of our products and product candidates; our ability to maintain adequate protection of our intellectual property; competition risks; the need for additional financing; the impact of government laws and regulations and the impact of the current global macroeconomic climate on our ability to source supplies for our operations or our ability or capacity to manufacture, sell and support the use of our products and product candidates in the future.
These and other significant factors are discussed in greater detail in MediWound’s annual report on Form 20-F for the year ended December 31, 2025, filed with the Securities and Exchange Commission (“SEC”) on March 5, 2026 and Quarterly Reports on Form 6-K and other filings with the SEC from time-to-time. These forward-looking statements reflect MediWound’s current views as of the date hereof and MediWound undertakes, and specifically disclaims, any obligation to update any of these forward-looking statements to reflect a change in their respective views or events or circumstances that occur after the date of this release except as required by law.
MediWound Contacts:
Hani Luxenburg
Chief Financial Officer
MediWound Ltd.
ir@mediwound.com
Daniel Ferry
Managing Director
LifeSci Advisors, LLC
daniel@lifesciadvisors.com
MediWound,Ltd.
Condensed Consolidated Statements of Financial Position
U.S. dollars in thousands
Dec 31,
2025
2024
CURRENT ASSETS:
Cash and cash equivalents and short-term bank deposits
53,140
43,161
Trade and other receivable, net
2,731
6,310
Inventories
4,093
2,692
Total current assets
59,964
52,163
NON-CURRENT ASSETS:
Other receivables and long-term restricted bank deposit
467
439
Property, plant and equipment
18,640
14,132
Right of use assets
7,151
6,663
Intangible assets
33
99
Total non-current assets
26,291
21,333
Total assets
86,255
73,496
CURRENT LIABILITIES:
Current maturities of long-term liabilities
870
612
Warrant
12,659
17,092
Trade payables and accrued expenses
7,648
5,281
Other payables
4,531
3,556
Total current liabilities
25,708
26,541
NON-CURRENT LIABILITIES:
Grants received in advance
-
736
Liabilities in respect of IIA grants
8,291
8,149
Lease liabilities
8,152
6,513
Severance pay liability, net
472
404
Total non-current liabilities
16,915
15,802
Total liabilities
42,623
42,343
Shareholders' equity*
43,632
31,153
Total liabilities & equity
86,255
73,496
*Shareholders' equity: Issued and Outstanding Ordinary shares of NIS 0.07 par value: 12,835,185 as of December 31, 2025 and 10,793,057 as of December 31, 2024
MediWound, Ltd.
Condensed Consolidated Statements of Profit or Loss and Other Comprehensive Income or Loss
U.S. dollars in thousands (except of share and per share data)
Twelve months ended
Three months ended
Dec 31,
Dec 31,
2025
2024
2025
2024
Total Revenues
16,959
20,222
1,867
5,840
Cost of revenues
13,705
17,588
1,589
4,937
Gross profit
3,254
2,634
278
903
Research and development
14,320
8,878
4,478
2,986
Selling and Marketing
5,765
4,936
1,380
1,470
General and administrative
8,448
8,202
2,237
2,530
Other (Income) expenses
(13
)
18
(17
)
18
Operating loss
(25,266
)
19,400)
)
(7,800
)
(6,101
)
Finance income (expenses), net
1,556
(10,763
)
690
2,211
Taxes on income
(169
)
(61
)
(73
)
(18
)
Net loss
(23,879
)
(30,224
)
(7,183
)
(3,908
)
Foreign currency translation adjustments
(21
)
7
(2
)
4
Total comprehensive loss
(23,900
)
(30,217
)
(7,185
)
(3,904
)
Basic and diluted net loss per share
(2.10
)
(3.03
)
(0.56
)
(0.36
)
Number of shares used in calculating basic and diluted loss per share
11,376,571
9,959,723
12,825,516
10,790,959
MediWound,Ltd.
Condensed Consolidated Statements of Cash Flows
U.S. dollars in thousands
Twelve months ended
Three months ended
Dec 31,
Dec 31,
2025
2024
2025
2024
Audited
Unaudited
Cash Flows from Operating Activities:
Net Loss
(23,879
)
(30,224
)
(7,183
)
(3,908
)
Adjustments to reconcile net loss to net cash used in operating activities:
Adjustments to profit and loss items:
Depreciation and amortization
1,860
1,483
690
397
Share-based compensation
3,108
3,138
662
822
Revaluation of warrants accounted at fair value
(2,158
)
10,704
(320
)
(1,964
)
Revaluation of liabilities in respect of IIA grants
380
752
(324
)
41
Revaluation of liabilities in respect of TEVA
-
770
-
-
Financing income and exchange differences of lease liability
1,725
487
439
249
Increase (decrease) in severance liability, net
31
(30
)
(21
)
16
Other income
(13
)
18
(17
)
18
Financial income, net
(1,891
)
(2,039
)
(550
)
(553
)
Unrealized foreign currency loss (gain)
(51
)
47
(17
)
(27
)
2,991
15,330
542
(1,001
)
Changes in assets and liability items:
Decrease (increase) in trade receivables
3,211
(1,141
)
2,753
(1,426
)
Decrease (increase) in inventories
(1,363
)
187
350
348
Decrease in other receivables
1,665
120
1,904
403
Increase (decrease) in trade payables and accrued expenses
2,350
406
(59
)
2,354
Increase in grants received in advance
-
1,181
-
1,181
Increase (decrease) in other payables
(1,096
)
517
(1,323
)
412
4,767
1,270
3,625
3,272
Net cash used in operating activities
(16,121
)
(13,624
)
(3,016
)
(1,637
)
MediWound, Ltd.
Condensed Consolidated Statements of Cash Flows
U.S. dollars in thousands
Cash Flows from Investing Activities:
Purchase of property and equipment
(5,505
)
(6,273
)
(2,452
)
(806
)
Interest received
1,591
2,252
182
664
Proceeds from (Investment in) short term bank deposits, net
(14,036
)
(4,376
)
(21,621
)
4,970
Net cash provided by (used in) investing activities
(17,950
)
(8,397
)
(23,891
)
4,828
Cash Flows from Financing Activities:
Repayment of lease liabilities
(1,212
)
(928
)
(345
)
(242
)
Proceeds from exercise of warrants and share options
3,630
1,210
6
-
Proceeds from issuance of shares
27,416
22,165
(753
)
(271
)
Repayments of IIA grants
(214
)
(219
)
-
-
Repayment of liabilities in respect of TEVA
-
(2,834
)
-
-
Net cash provided by (used in) financing activities
29,620
19,394
(1,092
)
(513
)
Exchange rate differences on cash and cash equivalent balances
95
(84
)
61
2
Increase (decrease) in cash and cash equivalents
(4,356
)
(2,711
)
(27,938
)
2,680
Balance of cash and cash equivalents at the beginning of the period
9,155
11,866
32,737
6,475
Balance of cash and cash equivalents at the end of the period
4,799
9,155
4,799
9,155
MediWound, Ltd.
Adjusted EBITDA
U.S. dollars in thousands
Twelve months ended
Three months ended
Dec 31,
Dec 31,
2025
2024
2025
2024
Net loss
(23,879
)
(30,224
)
(7,183
)
(3,908
)
Adjustments:
Financial income (expenses), net
1,556
(10,763
)
690
2,211
Other income (expenses), net
13
(18
)
17
(18
)
Taxes on income
(169
)
(61
)
(73
)
(18
)
Depreciation and amortization
(1,860
)
(1,483
)
(690
)
(397
)
Share-based compensation expenses
(3,108
)
(3,138
)
(662
)
(822
)
Total adjustments
(3,568
)
(15,463
)
(718
)
956
Adjusted EBITDA
(20,311
)
(14,761
)
(6,465
)
(4,864
)