Theravance Biopharma, Inc. Reports Fourth Quarter and Full Year 2025 Financial Results and Provides Corporate Update

Theravance Biopharma, Inc. Reports Fourth Quarter and Full Year 2025 Financial Results and Provides Corporate Update DUBLIN, March 19, 2026 /PRNewswire/ -- Theravance Biopharma, Inc. ("Theravance Biopharma" or the "Company") (NASDAQ: TBPH) today reported financial and operational results for the fourth quarter and full year of 2025.

"We ended 2025 on a positive note from a financial perspective, achieving another record quarter of non-GAAP profitability, hitting a new all-time high for YUPELRI ® brand-level profitability, and reaching $75 million in key sales-based milestones. These results highlight the strength and durability of our commercial asset, YUPELRI ®, our commitment to operating with financial and operational discipline, and the strength of our balance sheet," said Rick E Winningham, Chief Executive Officer of Theravance Biopharma. "Since announcing the CYPRESS study results earlier this month, we have made progress implementing an organizational restructuring to streamline costs and align resources with the commercial opportunity ahead of YUPELRI ®. We are confident that these actions, paired with the important work that the Board's Strategic Review Committee is doing to evaluate opportunities available to the Company, will enable Theravance to deliver on our goal of maximizing value for shareholders."

Strategic Review Committee

In 2024, the Theravance Board of Directors formed a Strategic Review Committee (the "Committee") composed entirely of independent directors to assess all strategic alternatives available to the Company. Since then, the Committee has been working on an ongoing basis with Lazard, its independent financial advisor, to evaluate opportunities to maximize shareholder value, including under multiple potential outcomes for the CYPRESS study, which the Company announced on March 3 rd did not meet the primary endpoint. Building upon this work, the Committee is acting with urgency to evaluate a broad range of value maximizing and tax efficient alternatives, including but not limited to a sale of the Company. In connection with the Company's March 3 rd announcement to wind down the ampreloxetine program and implement an organizational restructuring, the Committee has accelerated its evaluation of strategic alternatives for the Company. There can be no assurance that the Committee's strategic review process will result in any transaction. Theravance Biopharma does not intend to disclose further developments on this review process unless and until it determines that such disclosure is appropriate or necessary.

Operational Highlights

YUPELRI ® (revefenacin) inhalation solution, the first and only once-daily, nebulized LAMA (long-acting muscarinic antagonist) bronchodilator approved in the U.S. for the maintenance treatment of patients with chronic obstructive pulmonary disease (COPD):

TRELEGY

GSK reported fourth quarter 2025 global net sales of approximately $970 million (up 14% vs. the fourth quarter of 2024) and full year net sales of approximately $3.9 billion (up 13% vs. full year 2024) 6:

Organizational Restructuring Update

Fourth Quarter Financial Results

2026 Financial Guidance

Theravance Biopharma is implementing an organizational restructuring to streamline costs and align its resources with its commercial focus on YUPELRI. The restructuring will involve winding down the R&D function and significantly reducing the G&A function. The restructuring is expected to reduce operating expenses by approximately 60%, relative to 2025 actuals of $111.1 million. The full run-rate cost savings of approximately $70 million are expected to fully materialize in the third quarter of 2026.

Together, the cost savings from the restructuring and continued sales from YUPELRI are expected to result in the Company generating approximately $60 to $70 million of annualized cash flow, starting in the third quarter of 2026. This cash flow projection is comprised of an estimated $45 to $55 million of Income from Operations (excluding non-cash share-based compensation) and projected Interest and Other Income, and does not include potential income from the $100 million TRELEGY milestone.

The restructuring is expected to impact approximately 50% of the overall workforce. This reduction includes the complete wind-down of the R&D organization and a decrease of approximately 50% in G&A employees. These actions are expected to be implemented over the next two quarters, and the Company expects to incur approximately $5 to $7 million in one-time cash severance costs related to these actions.

Conference Call

Beginning with this quarter, earnings results will be released via press release only. The Company will not host a conference call or webcast to discuss quarterly results.

About Theravance Biopharma

Theravance Biopharma, Inc.'s focus is to deliver Medicines that Make a Difference ® in people's lives. In pursuit of its purpose, Theravance Biopharma leverages decades of expertise, which has led to the development of FDA-approved YUPELRI ® (revefenacin) inhalation solution indicated for the maintenance treatment of patients with chronic obstructive pulmonary disease (COPD). The Company is committed to creating/driving shareholder value.

For more information, please visit www.theravance.com.

THERAVANCE BIOPHARMA ®, THERAVANCE ® and the Cross/Star logo are registered trademarks of the Theravance Biopharma group of companies (in the U.S. and certain other countries).

YUPELRI ® is a registered trademark of Viatris Specialty LLC. Trademarks, trade names or service marks of other companies appearing on this press release are the property of their respective owners.

Forward-Looking Statements

This press release contains certain "forward-looking" statements as that term is defined in the Private Securities Litigation Reform Act of 1995 regarding, among other things, statements relating to goals, plans, objectives, expectations and future events. Theravance Biopharma, Inc. (the "Company") intends such forward-looking statements to be covered by the safe harbor provisions for forward-looking statements contained in Section 21E of the Securities Exchange Act of 1934, as amended, and the Private Securities Litigation Reform Act of 1995. Examples of such statements include statements relating to: the Company's expectations regarding its future profitability, expenses and uses of cash, the Company's goals, designs, strategies, plans and objectives, future growth of YUPELRI sales and future royalty payments, the winddown of the Company's ampreloxetine program and R&D function and significant reduction of its G&A function, the consideration of strategic alternatives for the Company, the ability to provide value to shareholders, the Company's regulatory strategies, the status of patent infringement litigation initiated by the Company and its partner against certain generic companies in federal district courts, and contingent milestone payments due to the Company from the sale of the Company's TRELEGY royalty interests. These statements are based on the current estimates and assumptions of the management of Theravance Biopharma as of the date of this press release and are subject to risks, uncertainties, changes in circumstances, assumptions and other factors that may cause the actual results of Theravance Biopharma to be materially different from those reflected in the forward-looking statements. Important factors that could cause actual results to differ materially from those indicated by such forward-looking statements include, among others, risks related to: factors that could increase the Company's expenses beyond its expectations and any factors that could adversely affect its profitability, whether the TRELEGY milestone thresholds will be achieved, delays or difficulties in winding down clinical studies, the timing of any potential strategic transaction with respect to the Company, if at all, risks of collaborating with or relying on third parties to develop, manufacture and commercialize products, and risks associated with establishing and maintaining sales, marketing and distribution capabilities with appropriate technical expertise and supporting infrastructure, the ability of the Company to protect and to enforce its intellectual property rights, volatility and fluctuations in the trading price and volume of the Company's shares, and general economic and market conditions. Other risks affecting the Company are in the Company's Form 10-Q filed with the SEC on November 12, 2025, and other periodic reports filed with the SEC. In addition to the risks described above and in Theravance Biopharma's filings with the SEC, other unknown or unpredictable factors also could affect Theravance Biopharma's results. No forward-looking statements can be guaranteed, and actual results may differ materially from such statements. Given these uncertainties, you should not place undue reliance on these forward-looking statements. Theravance Biopharma assumes no obligation to update its forward-looking statements on account of new information, future events or otherwise, except as required by law.

Non-GAAP Financial Measures

Theravance Biopharma provides a non-GAAP metric in this press release. Theravance Biopharma believes that non-GAAP net income (loss) provides meaningful information to assist investors in assessing prospects for future performance and actual performance as they provide better metrics for analyzing the performance of its business by excluding items that may not be indicative of core operating results and the Company's cash position. Because non-GAAP financial targets and metrics, such as non-GAAP net income (loss), are not standardized, it may not be possible to compare these measures with other companies' non-GAAP targets or measures having the same or a similar name. Thus, Theravance Biopharma's non-GAAP measures should be considered in addition to, not as a substitute for, or in isolation from, the Company's actual GAAP results and other targets.

Please see the appendix attached to this press release for a reconciliation of non-GAAP net income (loss) to its corresponding measure, net income (loss). A reconciliation of non-GAAP net income (loss) to its corresponding GAAP measure is not available on a forward-looking basis without unreasonable effort due to the uncertainty regarding, and the potential variability of, expenses and other factors in the future.

Contact:

[email protected]

650-808-4045

___________________

In the U.S., Viatris is leading the commercialization of YUPELRI, and the Company co-promotes the product under a profit and loss

sharing arrangement (65% to Viatris; 35% to the Company).

Payment from Royalty Pharma (RP) will be triggered if RP receives certain minimum royalty payments from GSK based on TRELEGY

global net sales.

Non-GAAP profit (loss) consists of GAAP net income (loss) before taxes less (i) share-based compensation expense, (ii) non-cash

interest expense, and (iii) non-recurring revenue and income items. See the section titled "Non-GAAP Financial Measures" for more

information.

Source: Viatris Customer Demand (Q3'25).

Source: IQVIA DDD, HDS, VA and Non-Reporting Hospital through Sept '25.

GSK-reported Net Sales in USD.

THERAVANCE BIOPHARMA, INC

CONDENSED CONSOLIDATED BALANCE SHEETS

(In thousands)

December 31,

2025

2024

Assets

(Unaudited)

(1)

Current assets:

Cash and cash equivalents and short-term marketable securities

315,357

88,350

Receivables from collaborative arrangements

45,539

18,440

Receivables from milestone and royalty assets

50,000

Other prepaid and current assets

7,564

4,277

Total current assets

418,460

161,067

Long-term marketable securities

11,128

Property and equipment, net

5,895

7,418

Operating lease assets

24,371

28,354

Future contingent milestone and royalty assets

144,200

Restricted cash

836

Other assets

24,880

12,286

Total assets

485,570

354,161

Liabilities and Shareholders' Equity

Current liabilities

38,302

32,085

Long-term operating lease liabilities

31,758

39,108

Future royalty payment contingency

32,795

30,334

Unrecognized tax benefits

85,679

75,199

Other long-term liabilities

313

1,890

Shareholders' equity

296,723

175,545

Total liabilities and shareholders' equity

485,570

354,161

________________________________

(1) The condensed consolidated balance sheet as of December 31, 2024 has been derived from the audited consolidated financial

statements included in the Company's Annual Report on Form 10-K for the year ended December 31, 2024

THERAVANCE BIOPHARMA, INC

CONDENSED CONSOLIDATED STATEMENTS OF OPERATIONS

(In thousands, except per share data)

Three Months Ended December 31,

Year Ended December 31,

2025

2024

2025

2024

(Unaudited)

Revenue:

Viatris collaboration agreement (1)

20,891

18,754

74,964

64,381

Licensing and milestone revenue

25,000

32,500

Total revenue

45,891

18,754

107,464

64,381

Costs and expenses:

Research and development (2)

7,362

9,452

37,414

37,643

Selling, general and administrative (2)

18,517

18,502

73,652

69,174

Impairment of long-lived assets (non-cash)

4,513

Total costs and expenses

25,879

27,954

111,066

111,330

Income (loss) from operations

20,012

(9,200)

(3,602)

(46,949)

Net gain on realized contingent milestone and royalty assets

75,137

TRELEGY milestone income

50,000

Interest expense (non-cash)

(583)

(643)

(2,461)

(2,546)

Interest income and other income, net

3,640

902

10,173

4,881

Income (loss) before income taxes

73,069

(8,941)

129,247

(44,614)

Provision for income tax expense

(12,045)

(6,587)

(23,352)

(11,804)

Net income (loss)

61,024

(15,528)

105,895

(56,418)

Net income (loss) per share:

Net income (loss) per share - basic

1.20

(0.31)

2.10

(1.15)

Net income (loss) per share - diluted

1.15

(0.31)

2.06

(1.15)

Shares used to compute net income (loss) per share - basis

50,868

49,306

50,317

48,847

Shares used to compute net income (loss) per share - diluted

53,053

49,306

51,507

48,847

Non-GAAP net income (loss)

3,131

(2,472)

(7,453)

(16,162)

________________________________

(1) While Viatris, Inc. records the totalYUPELRI net sales, the Company is entitled to a 35% share of the net profit (loss) pursuant to a co-promotion agreement

with Viatris as presented below:

Three Months Ended December 31,

Year Ended December 31,

(In thousands)

2025

2024

2025

2024

YUPELRI net sales (100% recorded byViatris)

70,563

66,680

266,600

238,626

YUPELRI net sales (Theravance Biopharma implied 35%)

24,697

23,339

93,310

83,520

(2) Amounts include share-based compensation expense as follows:

Three Months Ended December 31,

Year Ended December 31,

(In thousands)

2025

2024

2025

2024

Research and development

944

1,377

4,081

5,104

Selling, general and administrative

3,535

4,449

14,395

16,289

Total share-based compensation expense

4,479

5,826

18,476

21,393

THERAVANCE BIOPHARMA, INC

Reconciliation of GAAP Net Income (Loss) to Non-GAAP Net Income (Loss)

(In thousands)

Three Months Ended December 31,

Year Ended December 31,

2025

2024

2025

2024

(Unaudited)

GAAP net income (loss)

61,024

(15,528)

105,895

(56,418)

Adjustments:

Licensing revenue (1)

(25,000)

(32,500)

Net gain on realized contingent milestone and royalty assets (1)

(75,137)

TRELEGY milestone income (1)

(50,000)

Non-cash impairment expense of long-lived assets (1)

4,513

Share-based compensation expense

4,479

5,826

18,476

21,393

Non-cash interest expense

583

643

2,461

2,546

Income tax expense

12,045

6,587

23,352

11,804

Non-GAAP net income (loss)

3,131

(2,472)

(7,453)

(16,162)

(1) Non-recurring item

SOURCE Theravance Biopharma, Inc.