F2G Announces Abstracts Accepted for Oral and Poster Presentation at IDWeek 2026
MANCHESTER, United Kingdom, Oct. 06, 2026 (GLOBE NEWSWIRE) -- F2G Ltd. today announced abstracts accepted for oral and poster presentation at IDWeek 2026, taking place October 21–24, 2026, at the Walter E. Washington Convention Center in Washington, D.C.
The Global Phase 3 OASIS data have been accepted for late-breaking oral abstract presentation building on the positive topline results announced in June. The oral presentation will be accompanied by poster presentations highlighting long-term follow-up data and health-related quality-of-life outcomes in patients with invasive fungal infections who have limited or no treatment options following treatment with olorofim. The OASIS study was a collaboration between F2G and Shionogi & Co.Ltd.
Details of the IDWeek 2026 presentations include:
Session: Late Breaking Abstracts: Antimicrobials
Poster Session: Novel Agents (Poster P-4)
Poster Session: Medical Mycology
About the Phase 3 OASIS Study
The Phase 3 OASIS (Olorofim Aspergillus Infection Study) trial ( NCT05101187) was a global, randomized study that evaluated the efficacy and safety of olorofim versus AmBisome ® followed by standard of care in adult patients with invasive aspergillosis whose infection is either refractory to or unsuitable for azole therapy. OASIS was designed as a non-inferiority study using a non-inferiority margin of 20% comparing outcomes in 225 subjects randomized 2:1 to olorofim or AmBisome-based standard of care. Invasive aspergillosis is a life-threatening fungal infection with limited treatment options due to rising drug resistance and toxicity concerns 1,2,4. The study’s primary endpoint was all-cause mortality at Day 42, with additional measures of clinical response, safety, and quality of life.
About Study 32
Study 32 was a multicenter, open-label, Phase 2b study to evaluate the safety and efficacy of olorofim (formerly F901318) in patients ≥ 18 years of age with probable pulmonary invasive aspergillosis or proven invasive fungal infections due to Lomentospora prolificans, Scedosporium spp., Aspergillus spp., and other resistant fungi with limited or no treatment options. It enrolled patients between June 2018 and September 2022.
Enrolled patients received an initial loading dose of 150 mg BID (twice a day) of oral olorofim on day one, and subsequent oral doses of 90 mg BID for up to 90 days. Patients were followed for another four weeks after the end of treatment, while some received extended therapy for as long as thought clinically beneficial. For more information on Study 32, visit ClinicalTrials.gov ( NCT03583164). These data enable continued clinical development and support future regulatory and commercial planning.
About Olorofim
Olorofim (formerly, F901318) is F2G’s leading candidate from the orotomide class and has been studied in a recently completed global Phase 3 trial (“OASIS”, NCT05101187). Olorofim is a first-in-class antifungal with a novel mechanism of action, oral dosing, and activity against a wide range of Aspergillus species, including strains that are resistant to currently approved agents 1. If approved based on the Phase 3 OASIS data, olorofim will be the first novel mechanism agent for invasive aspergillosis in more than 20 years 1,2.
In the U.S., olorofim has received orphan drug status from the FDA for the treatment of invasive aspergillosis, scedosporiosis, invasive scopulariopsis, and coccidioidomycosis[ 5]. Olorofim has been granted Qualified Infectious Disease Product (QIDP) designation for several invasive fungal infections, including invasive aspergillosis and coccidioidomycosis 1.
Additionally, olorofim has also received two Breakthrough Therapy designations (BTD) from the FDA 1. The first BTD was for the treatment of invasive mold infections in patients with limited or no treatment options, including aspergillosis refractory or intolerant to currently available therapy, and infections due to Lomentospora prolificans, Scedosporium and Scopulariopsis species 1. The second BTD was for the treatment of central nervous system (CNS) coccidioidomycosis refractory or otherwise unable to be treated with standard of care therapy 1.
In Europe, olorofim has been granted orphan designation from the European Medicines Agency for the treatment of invasive aspergillosis, scedosporiosis, and invasive scopulariopsis 1.
Olorofim is an investigational therapy and has not been approved by any regulatory authorities.
About F2G
F2G is a clinical-stage biopharmaceutical company with operations in the UK, US, and Austria focused on the discovery and development of novel therapies to treat potentially life-threatening invasive fungal infections. F2G has discovered and developed a completely new class of antifungal agents called the orotomides, which selectively target a key enzyme in the pyrimidine biosynthesis pathway, a novel mechanism of action that is distinct from currently marketed antifungal agents. This mechanism provides the orotomides with fungicidal activity against a broad range of rare and resistant fungal mould infections. For more information, please visit: www.f2g.com
F2G Media Contact:
Luke Shiplo
LifeSci Communications
F2GMedia@lifescicomms.com
AmBisome ® is a registered trademark of Gilead Sciences, Inc. All other trademarks are the property of their respective owners.
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