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Form 8-K

sec.gov

8-K — ANAPTYSBIO, INC

Accession: 0001193125-26-396690

Filed: 2026-09-21

Period: 2026-09-21

CIK: 0001370053

SIC: 2834 (PHARMACEUTICAL PREPARATIONS)

Item: Financial Statements and Exhibits

Documents

8-K — anab-20260921.htm (Primary)

EX-99.1 (anab-ex99_1.htm)

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8-K

8-K (Primary)

Filename: anab-20260921.htm · Sequence: 1

8-K

false000137005300013700532026-09-212026-09-21

UNITED STATES

SECURITIES AND EXCHANGE COMMISSION

WASHINGTON, D.C. 20549

FORM 8-K

CURRENT REPORT

Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934

Date of Report (Date of earliest event reported): September 21, 2026

ANAPTYSBIO, INC.

(Exact name of Registrant as Specified in Its Charter)

Delaware

001-37985

20-3828755

(State or Other Jurisdiction

of Incorporation)

(Commission File Number)

(IRS Employer

Identification No.)

10770 Wateridge Circle, Suite 210

San Diego, California

92121

(Address of Principal Executive Offices)

(Zip Code)

Registrant’s Telephone Number, Including Area Code: 858 362-6295

N/A

(Former Name or Former Address, if Changed Since Last Report)

Check the appropriate box below if the Form 8-K filing is intended to simultaneously satisfy the filing obligation of the registrant under any of the following provisions:

☐Written communications pursuant to Rule 425 under the Securities Act (17 CFR 230.425)

☐Soliciting material pursuant to Rule 14a-12 under the Exchange Act (17 CFR 240.14a-12)

☐Pre-commencement communications pursuant to Rule 14d-2(b) under the Exchange Act (17 CFR 240.14d-2(b))

☐Pre-commencement communications pursuant to Rule 13e-4(c) under the Exchange Act (17 CFR 240.13e-4(c))

Securities registered pursuant to Section 12(b) of the Act:

Title of each class

Trading

Symbol(s)

Name of each exchange on which registered

Common stock, par value $0.001 per share

ANAB

The Nasdaq Stock Market LLC

Indicate by check mark whether the registrant is an emerging growth company as defined in Rule 405 of the Securities Act of 1933 (§ 230.405 of this chapter) or Rule 12b-2 of the Securities Exchange Act of 1934 (§ 240.12b-2 of this chapter).

Emerging growth company ☐

If an emerging growth company, indicate by check mark if the registrant has elected not to use the extended transition period for complying with any new or revised financial accounting standards provided pursuant to Section 13(a) of the Exchange Act. ☐

Item 2.02 Results of Operations and Financial Condition.

On September 21, 2026, AnaptysBio, Inc. (“AnaptysBio”) issued a press release announcing its financial results for the three months and transitional fiscal year ended June 30, 2026. A copy of the press release is attached as Exhibit 99.1 to this Current Report on Form 8-K.

The information in this Item 2.02, including Exhibit 99.1 to this Current Report on Form 8-K, shall not be deemed to be “filed” for purposes of Section 18 of the Securities Exchange Act of 1934, as amended, or otherwise subject to the liabilities of that section or Sections 11 and 12(a)(2) of the Securities Act of 1933, as amended. The information contained in this Item 2.02 and in the accompanying Exhibit 99.1 shall not be incorporated by reference into any registration statement or other document filed by AnaptysBio with the Securities and Exchange Commission, whether made before or after the date of this Current Report on Form 8-K, regardless of any general incorporation language in such filing (or any reference to this Current Report on Form 8-K generally), except as shall be expressly set forth by specific reference in such filing.

Item 9.01 Financial Statements and Exhibits.

(d) Exhibits

Exhibit Number

Exhibit Title or Description

99.1

Press release issued by AnaptysBio, Inc. regarding its financial results for the three months and transitional fiscal year ended June 30, 2026, dated September 21, 2026.

104

Cover Page Interactive Data File (the cover page XBRL tags are embedded within the inline XBRL document).

SIGNATURES

Pursuant to the requirements of the Securities Exchange Act of 1934, the registrant has duly caused this report to be signed on its behalf by the undersigned hereunto duly authorized.

AnaptysBio, Inc.

Date:

September 21, 2026

By:

/s/ Christopher M. Murphy

Name: Christopher M. Murphy

Title: Chief Financial Officer

EX-99.1

EX-99.1

Filename: anab-ex99_1.htm · Sequence: 2

EX-99.1

Exhibit 99.1

Anaptys Announces Second Quarter and Transitional Fiscal Year 2026 Financial Results and Provides Business Update

•

Jemperli global net sales of $644 million (£480 million) for the six months ended June 30, 2026, representing 34% year-over-year growth

•

Positive interim results from the pivotal AZUR-1 trial of Jemperli in untreated stage II/III dMMR/MSI-H locally advanced rectal cancer announced in July; FDA PDUFA action date of February 2027 with eligibility for expedited review through the National Priority Voucher program, which could result in an earlier FDA decision

•

Litigation with GSK and Tesaro: trial held in July; post-trial hearing scheduled for October 20, 2026, with a judgement anticipated in Q4 2026 or Q1 2027

SAN DIEGO, Sept. 21, 2026 — AnaptysBio, Inc. (Nasdaq: ANAB), a company focused on managing the financial collaborations for Jemperli with Tesaro, a GSK company, and Quimilza (imsidolimab) with Vanda, today reported financial results for the second quarter and transitional fiscal year ended June 30, 2026, and provided a business update.

“Jemperli continues to demonstrate robust year-over-year growth with major catalysts within the next 6 months including further sales acceleration ex-US, anticipated FDA approval of Jemperli in monotherapy in dMMR/MSI-H neoadjuvant rectal cancer, as well as a judgement expected in our litigation with GSK and Tesaro,” said Daniel Faga, president and chief executive officer. “In addition to Jemperli, we anticipate FDA approval of Quimilza in GPP in December 2026.”

GSK Jemperli Financial Collaboration

•

GSK announced strong commercial performance for Jemperli

o

$331 million (£248 million) in global net sales for the three months ended June 30, 2026, representing 26% year-over-year growth1

o

$644 million (£480 million) in global net sales for the six months ended June 30, 2026, representing 34% year-over-year growth1

•

Anaptys continues to expect to achieve >$390 million in annualized Jemperli royalties payable to Anaptys as early as 2029 at GSK’s peak monotherapy sales guidance of > $2.7 billion2

•

Anaptys estimates Sagard will have accrued ~$301 million in royalties and sales milestones through Q2 2026 and anticipates paydown of the remaining ~$299 million non-recourse debt monetization in the second half of 2027

•

Jemperli development and regulatory updates include:

o

AZUR-1 – pivotal Phase 2 – dostarlimab monotherapy in untreated stage II/III dMMR/MSI-H locally advanced rectal cancer

▪

In July 2026, GSK announced positive interim results from the trial, which met its primary objective by demonstrating a meaningful and sustained clinical complete response rate for 12 months (cCR12) with no detectable signs of cancer for at least one year

▪

The FDA has assigned a PDUFA action date of February 2027

•

Received an FDA Commissioner’s National Priority Voucher (CNPV) in Nov. 2025; eligible for an expedited review which could result in an earlier FDA decision

▪

GSK to present first results from the AZUR-1 trial as a late-breaking abstract at ESMO Congress 2026 in Madrid, Spain on Oct. 25, 2026

o

AZUR-2 – pivotal Phase 3 – dostarlimab versus standard of care in untreated TN40 or stage III dMMR/ MSI-H resectable colon cancer

▪

Data expected in 2028

o

AZUR-4 – Phase 2 – dostarlimab plus chemotherapy versus standard of care (chemotherapy) in untreated stage III MMRp/MSS resectable colon cancer

▪

Primary completion date in Q4 2026

o

JADE – pivotal Phase 3 – dostarlimab monotherapy versus placebo in locally advanced unresected head and neck squamous cell carcinoma (PD-L1 CPS≥1) post chemoradiation

▪

Data expected in 2028

Vanda Quimilza (imsidolimab) Financial Collaboration

•

FDA target action date (PDUFA) of Dec. 12, 2026, for Quimilza in generalized pustular psoriasis (GPP)

•

In August 2026, Vanda announced it received Orphan Designation from the European Commission for imsidolimab for the treatment of GPP

GSK and Tesaro Litigation Update

•

The trial was held before the Delaware Chancery Court from July 14-17, 2026

•

The Court has requested the parties submit post-trial briefs in advance of a post-trial hearing, which has been scheduled for October 20, 2026

o

Anaptys filed its opening post-trial brief on August 21, 2026, GSK and Tesaro will file their answering post-trial brief on or before September 25, 2026, and Anaptys will file its reply post-trial brief on or before October 9, 2026

•

Anaptys is seeking reversion of Jemperli rights as a remedy; the Company anticipates a judgement in Q4 2026 or Q1 2027

Second Quarter Financial Results

•

The separation of AnaptysBio and First Tracks Biotherapeutics was completed on April 20, 2026. Beginning in the second quarter of 2026, AnaptysBio reclassified historical First Tracks Biotherapeutics, Inc. related assets, liabilities and expenses as discontinued operations.

•

On May 18, 2026, Anaptys changed its fiscal year-end from December 31 to June 30. The Company will begin to file quarterly reports based on the new fiscal year beginning with the quarter ending September 30, 2026.

•

As of June 30, 2026, Anaptys has not repurchased any shares under its $100 million Stock Repurchase Plan, which will expire on December 31, 2026, may be suspended or discontinued at any time, and does not obligate the company to acquire any amount of common stock.

•

Cash, cash equivalents and investments totaled $164.1 million as of June 30, 2026, compared to $211.6 million as of December 31, 2025, for a decrease of $47.5 million due primarily to $72.9 million for operating activities offset by $25.4 million received from stock option exercises.

•

Collaboration revenue was $27.5 million and $53.0 million for the three and six months ended June 30, 2026, compared to $22.3 million and $50.0 million for the three and six months ended June 30, 2025. The increase is primarily due to Jemperli royalties increasing 25% and 34% for the three and six months ended June 30, 2026, offset by $9.7 million in revenue recognized for the Vanda license agreement for the three month and six months ended June 30, 2025.

•

General and administrative expenses were $16.0 million and $23.4 million for the three and six months ended June 30, 2026, compared to $4.0 million and $8.3 million for the three and six months ended June 30, 2025. The

increase was due primarily to legal costs for the separation of the company and the GSK and Tesaro lawsuit and non-cash stock compensation.

•

Research and development expenses from continuing operations were a negative $2.7 million for the six months ended June 30, 2026, compared to a negative $1.7 million six months ended June 30, 2025. The negative balance for the six months ended June 30, 2026, was primarily due adjustments related to the closeout of clinical contracts reducing expenses incurred prior to the separation.

•

Benefit for income taxes for continuing operations was $181.5 million for the six months ended June 30, 2026. The benefit recognized was primarily due to the release of the valuation allowance on deferred tax assets due to the anticipated usage of deferred tax assets in the future due to the separation from First Tracks Biotherapeutics.

•

Net income from continuing operations was $177.3 million and $176.4 million for the three and six months ended June 30, 2026, or a basic net income per share of $6.06 and $6.09, compared to a net income from continuing operations of $5.7 million and $16.6 million for the three and six months ended June 30, 2025, or a basic net income per share of $0.20 and $0.56.

Forward-Looking Statements

This press release contains forward-looking statements within the meaning of the “safe harbor” provisions of the Private Securities Litigation Reform Act of 1995, including, but not limited to future commercial and regulatory developments for Jemperli and Quimilza, future royalty amounts, the Company’s expected paydown of its obligations to Sagard, and the outcome of the Company’s ongoing litigation with GSK. Statements including words such as “plan,” “continue,” “expect,” or “ongoing” and statements in the future tense are forward-looking statements. These forward-looking statements involve risks and uncertainties, as well as assumptions, which, if they do not fully materialize or prove incorrect, could cause its results to differ materially from those expressed or implied by such forward-looking statements. Forward-looking statements are subject to risks and uncertainties that may cause the company’s actual activities or results to differ significantly from those expressed in any forward-looking statement, including risks and uncertainties related to commercial success of the Company’s licensed products, the company’s ability to protect its financial collaborations and return value to its shareholders, the company’s ability to operate efficiently with a limited staff, and other risks and uncertainties described under the heading “Risk Factors” in documents the company files from time to time with the Securities and Exchange Commission. These forward-looking statements speak only as of the date of this press release, and the company undertakes no obligation to revise or update any forward-looking statements to reflect events or circumstances after the date hereof.

About Anaptys

Anaptys manages the financial collaborations for Jemperli with GSK and Quimilza with Vanda, with a focus on protecting and returning the value of its royalties to shareholders. To learn more, visit www.AnaptysBio.com or follow us on LinkedIn.

Contact:

Chris Murphy

Chief Financial Officer

investors@anaptysbio.com

_______________________________________

1. GSK Q2 2026 earnings call, 7/28/2026

2. CEO Emma Walmsley, 2025 JP Morgan CEO Series fireside chat, 9/11/2025, “there's no change to our peak year sales overall ambition for Jemperli, that's for sure, which is far more than £2 billion.”; Converted from GBP to USD using Q3 2025 average exchange rate (1.35x)

AnaptysBio, Inc.

Consolidated Balance Sheets

(in thousands, except par value data)

June 30, 2026

December 31, 2025

ASSETS

Current assets:

Cash and cash equivalents

$

133,826

$

138,196

Receivables from collaborative partners

25,634

33,850

Short-term investments

30,317

73,442

Prepaid expenses and other current assets

8,650

—

Current assets of discontinued operations

—

104,762

Total current assets

198,427

350,250

Property and equipment, net

102

111

Deferred tax asset

106,639

—

Operating lease right-of-use assets

11,560

12,519

Other long-term assets

256

256

Non-current assets of discontinued operations

—

1,259

Total assets

$

316,984

$

364,395

LIABILITIES AND STOCKHOLDERS’ EQUITY (DEFICIT)

Current liabilities:

Accounts payable

$

4,394

$

3,871

Accrued expenses

28,798

32,674

Current portion of operating lease liability

2,161

2,080

Total current liabilities

35,353

38,625

Liability related to sale of future royalties

256,493

276,528

Long-term taxes payable

3,619

—

Operating lease liability, net of current portion

10,934

12,032

Stockholders’ equity:

Preferred stock, $0.001 par value, 10,000 shares authorized and no shares, issued or outstanding at June 30, 2026 and December 31, 2025, respectively

—

—

Common stock, $0.001 par value, 500,000 shares authorized, 29,728 shares and 28,019 shares issued and outstanding at June 30, 2026 and December 31, 2025, respectively

30

28

Additional paid in capital

652,269

809,765

Accumulated other comprehensive loss

(151

)

(24

)

Accumulated deficit

(641,563

)

(772,559

)

Total stockholders’ equity

10,585

37,210

Total liabilities and stockholders’ equity

$

316,984

$

364,395

AnaptysBio, Inc.

Consolidated Statements of Operations and Comprehensive Loss

(in thousands, except per share data)

Three Months Ended

June 30,

Six Months Ended

June 30,

2026

(unaudited)

2025

(unaudited)

2026

2025

(unaudited)

Collaboration revenue

$

27,488

$

22,263

$

53,044

$

50,034

Operating expenses:

Research and development

(2,704

)

(1,448

)

(2,668

)

(1,733

)

General and administrative

16,044

3,984

23,390

8,298

Total operating expenses

13,340

2,536

20,722

6,565

Income from operations

14,148

19,727

32,322

43,469

Other income (expense), net:

Interest income

1,486

2,102

3,252

5,402

Sublease income

526

—

526

—

Non-cash interest expense for the sale of future royalties

(20,333

)

(19,606

)

(41,192

)

(37,667

)

Other (expense) income, net

(1

)

3,544

(1

)

5,453

Total other expense, net

(18,322

)

(13,960

)

(37,415

)

(26,812

)

(Loss) income before income taxes

(4,174

)

5,767

(5,093

)

16,657

Benefit (provision) for income taxes

181,491

(39

)

181,451

(83

)

Income from continuing operations

177,317

5,728

176,358

16,574

Income (loss) from discontinued operations, net of tax

6,563

(44,358

)

(45,362

)

(94,533

)

Net income (loss)

183,880

(38,630

)

130,996

(77,959

)

Other comprehensive (loss) income:

Unrealized loss on available for sale securities

(5

)

(167

)

(127

)

(311

)

Comprehensive income (loss)

$

183,875

$

(38,797

)

$

130,869

$

(78,270

)

Net income (loss) per common share:

Income from continuing operations - basic

$

6.06

$

0.20

$

6.09

$

0.56

Income (loss) from discontinued operations - basic

$

0.22

$

(1.54

)

$

(1.57

)

$

(3.18

)

Net income (loss) per common share - basic

$

6.28

$

(1.34

)

$

4.52

$

(2.62

)

Income from continuing operations - diluted

$

4.93

$

0.19

$

4.71

$

0.54

Income (loss) from discontinued operations - diluted

$

0.18

$

(1.49

)

$

(1.21

)

$

(3.08

)

Net income (loss) per common share - diluted

$

5.11

$

(1.30

)

$

3.50

$

(2.54

)

Weighted-average number of shares outstanding:

Basic

29,264

28,810

28,979

29,722

Diluted

35,975

29,806

37,476

30,692

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Name of the Exchange on which a security is registered.

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Reference 1: http://www.xbrl.org/2003/role/presentationRef

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-Name Exchange Act

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-Subsection d1-1

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Boolean flag that is true when the Form 8-K filing is intended to satisfy the filing obligation of the registrant as soliciting material pursuant to Rule 14a-12 under the Exchange Act.

+ References

Reference 1: http://www.xbrl.org/2003/role/presentationRef

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Trading symbol of an instrument as listed on an exchange.

+ References

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Boolean flag that is true when the Form 8-K filing is intended to satisfy the filing obligation of the registrant as written communications pursuant to Rule 425 under the Securities Act.

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Reference 1: http://www.xbrl.org/2003/role/presentationRef

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