Form 8-K

8-K — MILESTONE SCIENTIFIC INC.

Accession: 0001493152-26-014892

Filed: 2026-04-02

Period: 2026-03-31

CIK: 0000855683

SIC: 3842 (ORTHOPEDIC, PROSTHETIC & SURGICAL APPLIANCES & SUPPLIES)

Item: Entry into a Material Definitive Agreement

Item: Financial Statements and Exhibits

Documents

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UNITED

STATES

SECURITIES

AND EXCHANGE COMMISSION

Washington,

D.C. 20549

FORM

8-K

CURRENT

REPORT

Pursuant

to Section 13 or 15(d) of the Securities Exchange Act of 1934

Date

of Report (Date of earliest event reported): March 31, 2026

Milestone

Scientific Inc.

(Exact

name of registrant as specified in its charter)

Delaware 001-14053

13-3545623

(State

or other jurisdiction

incorporation)

(Commission

File

Number)

(IRS

Employer

Identification

No.)

425

Eagle Rock Road, Ste 403,

Roseland,

New Jersey

07068

(Address of principal executive

offices) (Zip

Code)

Registrant’s

telephone number, including area code (973) 535-2717

N/A

(Former

name or former address, if changed since last report.)

Check

the appropriate box below if the Form 8-K filing is intended to simultaneously satisfy the filing obligation of the registrant under

any of the following provisions (see General Instructions A.2. below):

☐ Written

communications pursuant to Rule 425 under the Securities Act (17 CFR 230.425)

☐ Soliciting

material pursuant to Rule 14a-12 under the Exchange Act (17 CFR 240.14a-12)

☐ Pre-commencement

communications pursuant to Rule 14d-2(b) under the Exchange Act (17 CFR 240.14d-2(b))

☐ Pre-commencement

communications pursuant to Rule 13e-4(c) under the Exchange Act (17 CFR 240.13e-4(c)) Securities

registered pursuant to Section 12(b) of the Act:

Title

of each class

Trading

Symbol(s)

Name

on exchange on which registered

Common

Stock

MLSS

NYSE

American

Indicate

by check mark whether the registrant is an emerging growth company as defined in Rule 405 of the Securities Act of 1933 (§230.405

of this chapter) or Rule 12b-2 of the Securities Exchange Act of 1934 (§240.12b-2 of this chapter).

Emerging

growth company ☐

an emerging growth company, indicate by check mark if the registrant has elected not to use the extended transition period for complying

with any new or revised financial accounting standards provided pursuant to Section 13(a) of the Exchange Act ☐

Item

1.01 — Entry into a Material Definitive Agreement

March 31, 2026, Milestone Scientific Inc. (the “Company”) entered into an amendment (the “Amendment”) to the

Amended and Restated Memorandum of Understanding, dated January 13, 2026 (the “MOU”), with Innovest S.p.A., as the holder

of certain consent/blockage rights with respect to BP4 S.r.l., a society’ a responsibility’ limitation in liquidation (“BP4”).

According to BP4, it was then the owner of 11.31% of the outstanding shares of common stock of the Company

The

Amendment amends the MOU to, among other things, revise the definition of “Qualified Offering” and “Other Locked-Up

Parties” in order to facilitate an offering by the Company.

copy of the Amendment is attached hereto as Exhibit 10.1 and is incorporated herein by reference.

The

foregoing description of the material terms of the MOU does not purport to be complete and is qualified in its entirety by reference

to such an exhibit.

Item

9.01 — Financial Statements and Exhibits

(d)

Exhibits.

Exhibit

No.

Description

10.1

Amendment to Amended and Restated Memorandum of Understanding, by and between Innovest S.p.A. and Milestone Scientific Inc., dated March 31, 2026.

104

Cover

Page Interactive Data File (embedded within the Inline XBRL document)

SIGNATURES

Pursuant

to the requirements of the Securities Exchange Act of 1934, the Registrant has duly caused this report to be signed on its behalf by

the undersigned hereunto duly authorized.

MILESTONE

SCIENTIFIC INC.

Dated:

April 2, 2026

By:

/s/ Eric Hines

Eric

Hines

Chief

Executive Officer

EX-10.1

Filename: ex10-1.htm · Sequence: 2

Exhibit

10.1

MILESTONE

SCIENTIFIC INC.

425

Eagle Rock Road, Ste 403,

Roseland,

New Jersey 07068

of March 31, 2026

Innovest

S.p.A.

Corso

Venezia 44

Milano,

Italy 20121

Attn:

Giandomenico Trombetta, President and Managing Director

BP4

S.r.l. in liquidazione

Corso

Venezia 44 Milano

Attn:

Pedro Palau, Liquidator and Legal Representative

Re:

Amendment

of Amended and Restated Memorandum of Understanding

Dear

Sirs:

Reference

is made to that certain Amended and Restated Memorandum of Understanding dated January 13, 2026 (the “MOU”) by and

between Innovest S.p.A. (“Innovest”), as the holder of certain consent/blockage rights with respect to BP4 S.r.l.,

societa’ a responsabilita’ limitata in liquidazione (“BP4”), according to BP4’s corporate bylaws,

in the person of Gian Domenico Trombetta as a duly authorized representative of Innovest, and Milestone Scientific Inc., a Delaware corporation

(the “Company”). All terms used herein as defined terms but not defined herein shall have the meanings ascribed thereto

in the MOU.

The

purpose of this letter is to modify the MOU in certain respects, including the conditions to be satisfied for each of the BP4 Parties

to enter into Lock-Up Agreements. Accordingly, the parties hereby amend the MOU, as follows:

In paragraph 5 of the MOU, the references to January 31, 2026

shall be changed to refer to April 17, 2026 (provided, that if the Company is then working on a capital raise that upon consummation

would be a Qualified Offering (as amended in accordance with paragraph 2 below), then such April 17, 2026 date shall automatically be

extended until May 1, 2026.

In Annex A of the MOU, a “Qualified Offering” shall

mean the Company’s consummation of one or more offerings of its securities within forty-five (45) days from the date hereof with

aggregate gross proceeds to the Company of at least $900,000 and up to 19.99% of the number of outstanding shares of the Company (which

at the closing price of the Company’s shares on March 17, 2026 of $0.29 would be approximately $2,300,000), on terms and conditions

materially similar to those terms and conditions furnished to Innovest.

In Annex A of the MOU, “Other Locked-Up Parties”

shall mean each of the following:

●

Each

of the directors of the Company re-elected at the December 18, 2025 Annual Meeting of the stockholders of the Company;

●

Each

of the officers of the Company; and

●

United

Systems and its affiliates.

Except

as set forth above, the MOU shall continue in full force and effect.

consideration of the approval, execution and delivery of this letter, the Company hereby undertakes and irrevocably commits that, within

five (5) business days following the date on which both Innovest and BP4 have duly executed and returned this letter as evidence of their

approval of MOU Amendments, the Company shall pay to BP4 the further amount of USD 27,500 pursuant to Article 5 of the MOU, in respect

of additional disbursements accumulated in connection with the transaction contemplated by the MOU, it being understood that such payment

shall be subject, together with any prior payments made pursuant to Article 5 of the MOU, to the aggregate cap of USD 100,000 expressly

provided for therein.

[Remainder

of page intentionally blank]

Innovest S.p.A.

page 2

Please

evidence your consent to the matters set forth in this letter by signing and returning a copy of this letter.

Sincerely,

Milestone

Scientific Inc.

By: /s/

Eric Hines

Name: Eric

Hines

Title: President

and Chief Executive Officer

AGREED:

The

undersigned, as the holder of certain consent/blockage rights with respect to BP4 according to BP4’s corporate bylaws, hereby agrees

to amend the MOU as contemplated hereby.

Innovest S.p.A.

By:

/s/ G D Trombetta

Name:

Gian Domenico Trombetta

Title:

President and Managing Director

The

undersigned, as liquidator and legal representative of BP4 S.r.l. in liquidazione, duly authorized pursuant to the resolutions adopted

at the Meeting, hereby approves the MOU Amendments as set forth in this letter.

BP4 S.r.l. in liquidazione

By: /s/

P Palau

Name: Dottor

Pedro Palau

Title: iL

Liquidatore and Legal Representative

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