Form 8-K

8-K — BullFrog AI Holdings, Inc.

Accession: 0001493152-26-016378

Filed: 2026-04-13

Period: 2026-04-13

CIK: 0001829247

SIC: 2834 (PHARMACEUTICAL PREPARATIONS)

Item: Other Events

Item: Financial Statements and Exhibits

Documents

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UNITED

STATES

SECURITIES

AND EXCHANGE COMMISSION

Washington,

DC 20549

FORM

8-K

CURRENT

REPORT

Pursuant

to Section 13 or 15(d) of the

Securities

Exchange Act of 1934

Date

of Report (Date of earliest event reported): April 13, 2026

BULLFROG

AI HOLDINGS, INC.

(Exact

name of Registrant as specified in its charter)

Nevada

001-41600

84-4786155

(State or other jurisdiction

of incorporation)

(Commission

File

Number)

(I.R.S.

Employer

Identification

No.)

325

Ellington Blvd, Unit 317

Gaithersburg,

MD 20878

(Address

of principal executive offices) (Zip Code)

Registrant’s

telephone number, including area code: (240) 658-6710

Not

Applicable

(Former

name or former address, if changed since last report)

Check

the appropriate box below if the Form 8-K filing is intended to simultaneously satisfy the filing obligation of the registrant under

any of the following provisions (see General Instruction A.2. below):

☐

Written

communications pursuant to Rule 425 under the Securities Act (17 CFR 230.425)

☐

Soliciting

material pursuant to Rule 14a-12 under the Exchange Act (17 CFR 240.14a-12)

☐

Pre-commencement

communications pursuant to Rule 14d-2(b) under the Exchange Act (17 CFR 240.14d-2(b))

☐

Pre-commencement

communications pursuant to Rule 13e-4(c) under the Exchange Act (17 CFR 240.13e-4(c))

Securities

registered pursuant to Section 12(b) of the Act:

Title

of each class

Trading

Symbol(s)

Name

of each exchange on which registered

Common

Stock, par value $0.00001 per share

BFRG

The

Nasdaq Stock Market LLC

(The

Nasdaq Capital Market)

Tradeable

Warrants

BFRGW

The

Nasdaq Stock Market LLC

(The

Nasdaq Capital Market)

Indicate

by check mark whether the registrant is an emerging growth company as defined in Rule 405 of the Securities Act of 1933 (§230.405

of this chapter) or Rule 12b-2 of the Securities Exchange Act of 1934 (§240.12b-2 of this chapter).

Emerging

growth company ☒

an emerging growth company, indicate by check mark if the registrant has elected not to use the extended transition period for complying

with any new or revised financial accounting standards provided pursuant to Section 13(a) of the Exchange Act. ☐

Item

8.01 Other Events.

April 13, 2026, BullFrog AI Holdings, Inc. issued a letter to its stockholders. A copy of the letter to stockholders is attached hereto

and incorporated herein by reference in its entirety as Exhibit 99.1.

Item

9.01 Financial Statements and Exhibits.

(d)

Exhibits.

The

following exhibit is being furnished herein:

99.1

Press release, dated April 13, 2026

104

Cover Page Interactive Data File (formatted as Inline

XBRL)

SIGNATURE

Pursuant

to the requirements of the Securities Exchange Act of 1934, the Registrant has duly caused this report to be signed on its behalf by

the undersigned hereunto duly authorized.

Date:

April 13, 2026

BullFrog AI Holdings, Inc.

By:

/s/

Vininder Singh

Name:

Vininder

Singh

Title:

Chief

Executive Officer

EX-99.1

Filename: ex99-1.htm · Sequence: 2

Exhibit

99.1

BullFrog

AI Provides Business Update: Strengthened Balance Sheet Supports Continued Execution as Company Aims to Ramp Commercial Activity with

Global Pharmaceutical and Biotechnology Partners

First

commercial agreement with a top 5 global pharmaceutical company anchors a growing pipeline of enterprise discussions; runway secured

into late 2027

GAITHERSBURG,

Md., April 13, 2026 (GLOBE NEWSWIRE) — BullFrog AI Holdings, Inc. (Nasdaq: BFRG; BFRGW) (“BullFrog AI” or the “Company”),

a technology company using artificial intelligence and machine learning to turn complex biomedical data into actionable insights, today

issued the following letter to shareholders from Vin Singh, Founder and CEO:

Dear

Fellow Shareholders,

BullFrog

AI enters the second quarter of 2026 well-capitalized, at commercial stage, and in active discussions with consequential pharmaceutical

and biotechnology organizations. We just closed our first agreement with a top 5 global pharmaceutical company, secured the financial

runway to execute our strategy into late 2027, and are deeply engaged with an industry that is no longer evaluating whether to embrace

AI-driven drug discovery — but deciding with whom.

The

transformation of pharmaceutical R&D through artificial intelligence is no longer a thesis — it is a market reality being priced

in real time. In particular, news of Anthropic’s reported $400 million acquisition of a pre-commercial stage AI drug discovery

startup sent an unambiguous signal about the value sophisticated capital is now placing on purpose-built, biology-native AI platforms.

This transaction, among others, points to an industry that is currently focused on exploring and pursuing artificial intelligence solutions

to power and advance their R&D programs.

CRITICAL COMMERCIAL AGREEMENT — AND THE FOUNDATION THAT EARNED IT

March 30, 2026, we announced a commercial feasibility agreement with a top 5 global pharmaceutical company by 2025 revenue. Under the

agreement, our proprietary bfLEAP® platform will identify and prioritize novel drug targets in major depressive disorder

— a market valued at more than $8 billion in 2025 and projected to exceed $11 billion by 2032. The agreement includes milestone

payments tied to defined deliverables and provides our partner with an option to secure exclusive rights to a final selected target candidate

for research and development purposes.

This

milestone agreement did not emerge in isolation. BullFrog AI’s technology is derived from research originally conducted at the

Johns Hopkins University Applied Physics Laboratory. Our ongoing collaboration with the Lieber Institute for Brain Development gives

us access to a proprietary dataset of more than 2,800 human brain samples — one of the most scientifically rich neuropsychiatric

resources available. Applied against that dataset, our platform has already identified novel drug targets and biological subgroups across

schizophrenia, bipolar disorder, and MDD. This agreement is the commercial translation of that upstream scientific work reaching the

largest companies in the industry — and a powerful validation of its real-world utility.

COMPLETE, DIFFERENTIATED AI PLATFORM

With

the March 2026 launch of bfARENAS™, we believe BullFrog AI now offers the only fully integrated end-to-end AI platform purpose-built

for pharmaceutical R&D — spanning the complete journey from raw data to strategic decision:

bfPREP™

harmonizes complex, fragmented biomedical data into structured, AI-ready assets — compressing data preparation timelines from months

to days and creating a reliable foundation for downstream analysis.

bfLEAP®

applies causal network inference and machine learning to identify drug targets, patient subgroups, and disease drivers from multimodal

datasets — generating explainable insights built to withstand scientific and regulatory scrutiny.

bfARENAS™

translates biological insight into ranked, defensible portfolio and clinical trial design decisions evaluated across multiple strategic

scenarios — directly addressing one of the industry’s most persistent decision-making failure modes.

Enterprise

pharmaceutical organizations seek to adopt AI at scale within their existing infrastructure — not integrate a patchwork of point

solutions. Our platform aims to meet them where their data lives, and our recent commercial agreement demonstrates validation of our

fully integrated stack.

FINANCIAL

POSITION AND OPERATING DISCIPLINE

have taken deliberate steps to fortify our financial foundation. Through a series of financing activities, involving sales under our

at-the-market and equity-line-of-credit facilities, completed in late March 2026, we believe we have stockholders’ equity in excess

of $2.5 million in compliance with Nasdaq’s minimum stockholders’ equity listing standard. In addition, based on our current

cash burn-rate, the proceeds of such financing activities should provide the capital necessary to support our operational plan into late

2027.

Our

operating cost structure remains intentionally lean. This discipline creates significant operating leverage as commercial revenue scales:

even a single material partnership has the potential to meaningfully extend our runway, reduce dilution risk, and shift the trajectory

of the business.

PRIORITIES

FOR THE YEAR AHEAD

Our

near-term focus is clear. We are planning to deepen the relationship with our top 5 pharma company customer into a broader, multi-program

partnership; advance an active pipeline of discussions with global pharmaceutical and biotechnology organizations across a range of transaction

structures; expand direct engagement around bfPREP™ and bfARENASTM as entry points for broader platform adoption and

large strategic partnerships; and continue building the peer-reviewed scientific evidence base that underpins enterprise-level commercial

conversations.

established our AI technology years ago — and we are now converting it into the commercial outcomes that reflect its value. We

look forward to updating you as we deliver.

Sincerely,

Vin

Singh

Founder

and CEO

About

BullFrog AI

BullFrog

AI leverages artificial intelligence and machine learning to advance drug discovery and development. Through collaborations with leading

research institutions, BullFrog AI uses causal AI in combination with its proprietary bfLEAP® platform to analyze complex

biological data, aiming to streamline therapeutics development and reduce failure rates in clinical trials. For more information visit

BullFrog AI at: https://bullfrogai.com.

Safe

Harbor Statement

This

press release contains forward-looking statements. We base these forward-looking statements on our expectations and projections about

future events, which we derive from the information currently available to us. Such forward-looking statements relate to future events

or our future performance, including: our financial performance and projections; our revenue and earnings; and our business prospects

and opportunities. You can identify forward-looking statements by those that are not historical in nature, particularly those that use

terminology such as “may,” “should,” “could,” “will,” “expects,” “anticipates,”

“contemplates,” “estimates,” “believes,” “plans,” “aims,” “projected,”

“predicts,” “potential,” or “hopes” or the negative of these or similar terms. In evaluating these

forward-looking statements, you should consider various factors, including: our ability to change the direction of the Company; our ability

to keep pace with new technology and changing market needs; our and our partners’ ability to market and sell our offerings and

services, including BullFrog Data Networks™; our ability to maintain compliance with Nasdaq listing rules; and the competitive

environment of our business. These and other factors may cause our actual results to differ materially from any forward-looking statement.

Forward-looking statements are only predictions. The forward-looking events discussed in this press release and other statements made

from time to time by us or our representatives, may not occur, and actual events and results may differ materially and are subject to

risks, uncertainties, and assumptions about us. We are not obligated to publicly update or revise any forward-looking statement, whether

as a result of uncertainties and assumptions, the forward-looking events discussed in this press release and other statements made from

time to time by us or our representatives might not occur.

Contact:

Investors:

CORE

ir@bullfrogai.com

Media:

CORE

pr@bullfrogai.com

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