Poxel Reports First Quarter 2026 Revenue and Provides a Business Update

Poxel Reports First Quarter 2026 Revenue and Provides a Business Update LYON, France--( BUSINESS WIRE)--Regulatory News:

Poxel (Euronext: POXEL - FR0012432516), a clinical-stage biopharmaceutical company developing innovative treatments for severe chronic diseases with metabolic pathophysiology, including metabolic dysfunction-associated steatohepatitis (MASH) and rare metabolic diseases, today announced its revenue for the first quarter ended March 31, 2026, and provided a business update.

Commercial and Clinical Activity Update

TWYMEEG ® (Imeglimin)

Consolidated Revenue for the First Quarter of 2026

EUR (in thousands)

Q1 2026

3 months

Q1 2025

3 months

Sumitomo Pharma agreement

1 277

1 066

Other

Total consolidated revenue

1 277

1 066

* Unaudited data

About Poxel

Poxel is an international biopharmaceutical company at the commercial and clinical development stage, specialized in the development of innovative treatments for severe chronic diseases with metabolic pathophysiology, including rare metabolic diseases and hypertrophic cardiomyopathy (HCM).

TWYMEEG ® (Imeglimin), its first-in-class product targeting mitochondrial dysfunction, is marketed in Japan for the treatment of type 2 diabetes by Sumitomo Pharma, Poxel’s strategic partner for imeglimin in this territory. Poxel expects to receive royalties as well as sales-based payments from TWYMEEG ®.

For the treatment of MASH, PXL065 a deuterium-stabilized R-pioglitazone, achieved its primary endpoint in the Phase 2 DESTINY-1 study.

PXL770 is focused on rare diseases, notably autosomal dominant polycystic kidney disease (ADPKD). On March 31, 2026, Poxel announced the divestment of PXL770 to Scynexis for a total potential consideration of up to $196 million. The Company received an upfront payment of $8 million, with additional near-term development milestone payments of up to $8 million and up to $180 million in commercial milestone payments. Scynexis will develop PXL770 in its potential ADPKD indications.

Poxel is listed on Euronext Paris, is headquartered in Lyon, France, and has subsidiaries in Boston, MA, and Tokyo, Japan.

For more information, please visit: www.poxelpharma.com.

All statements other than statements of historical fact included in this press release concerning future events are subject to (i) change without notice and (ii) factors beyond the Company's control. These statements may include, but are not limited to, any statements preceded by, followed by, or including words such as ‘objective,’ ‘believe,’ ‘expect,’ ‘aim,’ ‘intend,’ ‘may,’ ‘anticipate,’ ‘estimate,’ ‘plan,’ ‘project,’ ‘will,’ ‘could,’ ‘likely,’ ‘should,’ and other words and terms of similar meaning, or the negative form of these words and terms. Forward-looking statements are subject to inherent risks and uncertainties beyond the Company's control that could cause the Company's actual results or performance to differ materially from the results or performance expected, expressed or implied in such forward-looking statements. Actual events or results may differ from those described in this document due to a number of risks or uncertainties described in the Company's 2024 Universal Registration Document available on the Company's website and that of the AMF ( https://www.amf-france.org/fr). The Company does not endorse and is not responsible for the content of external hyperlinks mentioned in this press release.

Glossary

For the sake of clarity and transparency, below is a list of words and/or expressions used in this press release or in other communications issued by Poxel:

Converted to JPY-EUR exchange rate = 183.44

Sumitomo Parma's fiscal year 2025 ends March 31, 2026

According to Sumitomo Pharma’s fiscal year 2025 guidance

According to Sumitomo Pharma’s fiscal year 2026 guidance

Sumitomo Parma's fiscal year 2026 ends March 31, 2027