Form 8-K

8-K — Transcode Therapeutics, Inc.

Accession: 0001104659-26-112826

Filed: 2026-10-01

Period: 2026-10-01

CIK: 0001829635

SIC: 2834 (PHARMACEUTICAL PREPARATIONS)

Item: Entry into a Material Definitive Agreement

Item: Triggering Events That Accelerate or Increase a Direct Financial Obligation or an Obligation under an Off-Balance Sheet Arrangement

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UNITED STATES

SECURITIES AND EXCHANGE COMMISSION

Washington, D.C. 20549

FORM 8-K

CURRENT REPORT

Pursuant to Section 13 or 15(d)

of the Securities Exchange Act of 1934

Date of Report (Date of earliest event reported):

October 1, 2026

TRANSCODE

THERAPEUTICS, INC.

(Exact name of registrant as specified in its

charter)

Delaware

001-40363

81-1065054

(State or other jurisdiction

of incorporation)

(Commission

File Number)

(I.R.S. Employer

Identification No.)

TransCode

Therapeutics, Inc.

Liberty Square, #2382

Boston, Massachusetts

02109

(Address

of principal executive offices, including zip code)

(857)

837-3099

(Registrant’s

telephone number, including area code)

Not Applicable

(Former Name or Former Address, if Changed

Since Last Report)

Check the appropriate box below if the Form 8-K

filing is intended to simultaneously satisfy the filing obligation of the registrant under any of the following provisions:

Written communications pursuant to Rule 425 under the Securities Act (17 CFR 230.425)

Soliciting material pursuant to Rule 14a-12 under the Exchange Act (17 CFR 240.14a-12)

Pre-commencement communications pursuant to Rule 14d-2(b) under the Exchange Act (17 CFR

240.14d-2(b))

Pre-commencement communications pursuant to Rule 13e-4(c) under the Exchange Act (17 CFR

240.13e-4(c))

Securities registered pursuant to Section 12(b) of the Act.

Title of each class

Trading symbol(s)

Name of each exchange on which

registered

Common

Stock, par value $0.0001 per share

RNAZ

The Nasdaq

Capital Market

Indicate by check mark whether the registrant

is an emerging growth company as defined in Rule 405 of the Securities Act of 1933 (§ 230.405 of this chapter) or Rule 12b-2

of the Securities Exchange Act of 1934 (§ 240.12b-2 of this chapter).

Emerging

growth company x

If an emerging growth company, indicate by check

mark if the registrant has elected not to use the extended transition period for complying with any new or revised financial accounting

standards provided pursuant to Section 13(a) of the Exchange Act. ¨

Item 1.01 Entry into a Material Definitive Agreement

As previously disclosed

by TransCode Therapeutics, Inc. (the “Company”) in a Current Report on Form 8-K filed with the Securities and Exchange Commission

(the “SEC”) on April 7, 2026, the Company entered into a Standby Equity Purchase Agreement (the “SEPA”) with YA

II PN, Ltd., a Cayman Islands exempt limited partnership (“Yorkville”) dated as of April 6, 2026, pursuant to which the Company

has the right to sell Yorkville up to $14 million of shares of the Company’s common stock, par value $0.0001 per share (“Common

Stock”). In connection with the SEPA, Yorkville also agreed to advance the Company up to $6.0 million, less certain amounts, to

be paid in two tranches, in exchange for the Company’s issuance to Yorkville of convertible promissory notes (each, a “Convertible

Note” and, together, the “Convertible Notes”). Under the terms of the Convertible Notes, an “Amortization Event”

is deemed to occur if the daily VWAP (as defined in the Convertible Notes) of the Common Stock is less than $1.72 (the “Floor Price”)

for five trading days during a period of seven consecutive trading days (a “Floor Price Event”). From September 11, 2026 to

September 30, 2026, the daily VWAP of the Common Stock was less than the Floor Price for 10 trading days out of 14 trading days.

On October 1, 2026, the

Company and Yorkville executed a waiver, in which the Company agreed to make a prepayment of $840,975 in accordance with Section 1(f)

of the Convertible Notes (the “Prepayment”), which amount includes payment of $759,000 outstanding principal of the Convertible

Notes, $75,900 prepayment premium and $6,075 of accrued interest. In consideration for the Prepayment, Yorkville agreed to waive the occurrence

of any Amortization Event that may be deemed to have occurred on or prior to September 30, 2026 and to waive any Amortization Event that

may be deemed to occur through October 31, 2026. On October 1, 2026, the Company made the Prepayment. Following the Prepayment, the aggregate

principal amount outstanding under the Convertible Notes is approximately $4.1 million.

Pursuant to the terms

of the Convertible Notes, upon the occurrence of an Amortization Event, the Company would be obligated to make monthly payments to Yorkville

beginning on the seventh trading day after the date upon which the Amortization Event occurred and continuing on the same day of each

successive calendar month in an amount equal to the sum of (i) 18% of the outstanding principal of the Convertible Notes as of the Amortization

Event Date (or the outstanding principal if less than such amount), plus (ii) 10% of the principal amount being paid in respect of such

Amortization Principal Amount, plus (iii) all accrued and unpaid interest thereunder as of each payment date. Such monthly payments would

be required to be made until the entire outstanding principal amount of the Convertible Notes has been repaid, or the obligation of the

Company has ceased because the daily VWAP is greater than the Floor Price for 10 consecutive trading days, unless a subsequent Amortization

Event occurs.

Item 2.04 Triggering Events That Accelerate or Increase a Direct Financial Obligation or an Obligation under

an Off-Balance Sheet Arrangement

The information set forth

in Item 1.01 of this Current Report is incorporated herein by reference.

SIGNATURES

Pursuant to the requirements

of the Securities Exchange Act of 1934, the Registrant has duly caused this report to be signed on its behalf by the undersigned hereunto

duly authorized.

TRANSCODE THERAPEUTICS, INC.

By:

/s/ Philippe P.

Calais

Name: Philippe P. Calais

Title: Chief Executive Officer

October 1, 2026

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Entity Incorporation, State or Country Code

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